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US 2017/0246261 A1Published application
Antiviral treatment with low immunogenicity
AssigneeAgenovir Corporation
InventorsEd Mocarski, Stephen R. Quake, Xin Cindy Xiong
Life of this patent
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Abstract
Compositions and methods are disclosed for reducing toxicity and immunogenicity of nucleases, especially when in use for cutting viral nucleic acids in host cells. Different nucleases that cut the same target are delivered at different times to avoid an immune response that interferes with a therapeutic effect of the nucleases.
Claims17
A method for delivering a nuclease to cells, the method comprising:
- providing to cells a first nuclease that cuts a target site in a target nucleic acid;
- and
- providing to the cells a second nuclease that cuts the target site, wherein the first nuclease and the second nuclease do not generate the same antigenic response.
Dependencies are inferred from the claim text.