Agent, product and use
AssigneesFundacióN Pedro Barrié De La Maza, Conde De Fenosa, Sergas, University of Santiago de Compostela, Fundacion Ramon Dominguez, Biomerix Corporation
InventorsAlexandre DE LA FUENTE GONZALEZ, Rafael LOPEZ, Miguel Abal POSADA, Lawrence Patrick LAVELLE, Jr.
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Abstract
The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.
Claims31
An agent for modulating metastatic tumor cell dissemination comprising an extracellular matrix (ECM) protein or adhesion molecule and a polycarbonate polyurethane matrix.
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A method of attracting or capturing tumor cells in a subject comprising administering to the subject an agent for modulating tumor cell dissemination comprising an extracellular matrix (ECM) protein or adhesion molecule and a polycarbonate polyurethane matrix.
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A method of manufacturing an agent for modulating metastatic tumor cell dissemination, the method comprising the steps of:
- preparing a suspended solution of an ECM protein;
- coating a polycarbonate polyurethane matrix by saturation within the solution of the ECM protein;
- and
- lyophilization of the the ECM protein within the polycarbonate polyurethane matrix to form the agent for modulating metastatic tumor cell dissemination.
Dependencies are inferred from the claim text.