Self-assembling tripeptides
AssigneeUniversity of Strathclyde
InventorsRein ULIJN, Tell TUTTLE, Pim FREDERIX, Gary SCOTT, Yousef ABUL-HAIJA
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Abstract
The present invention relates to a method of predicting the propensity of tripeptides to from aggregates in solution. The present invention also provides tripeptides which are able to form aggregates in solution, as well as uses thereof. The present invention also provides nanostructures formed by self-aggregation of tripeptides of the present invention. The present invention also provides pH responsive aggregates as well as methods of screening for the ability of a tripeptide to form a pH dependent aggregate or gel.
Claims31
A solution comprising a self-aggregated tripeptide, the tripeptide having the formula:
- A1-A2-A3
- wherein
- A1 is a hydrogen bond donating amino acid, such as K, R, S, T, or P, H, or W, or F;
- A2 is an aromatic amino acid, such as F, Y, W, or H;
- A3 is an aromatic amino acid, such as F, Y, or W, or a negatively charged amino acid such as D or E.
A solution comprising a self-aggregated tripeptide, wherein the tripeptide is identified in Table 2.
A method of producing a peptide capable of self-aggregation in solution, the method comprising:
- identifying a peptide by determining a hydrophilicity-adjusted measure of propensity for aggregation (APH) for the peptide, the APH being determined by adjusting a measure of propensity of aggregation (AP) for the peptide in dependence on a measure of hydrophilicity for the peptide;
- and
- synthesising the peptide.
A method of producing a nanostructure comprising a peptide capable of self-aggregation in solution, the method comprising:
- identifying a peptide by determining a hydrophilicity-adjusted measure of propensity for aggregation (APH) for the peptide, the APH being determined by adjusting a measure of propensity of aggregation (AP) for the peptide in dependence on a measure of hydrophilicity for the peptide;
- synthesising the peptide;
- and
- allowing the peptide to aggregate in solution.
A method of identifying a peptide for aggregation in solution, the method comprising identifying a peptide by determining a hydrophilicity-adjusted measure of propensity for aggregation (APH) for the peptide, the APH being determined by adjusting a measure of propensity of aggregation (AP) for the peptide in dependence on a measure of hydrophilicity for the peptide.
Dependencies are inferred from the claim text.