Methods and compositions for enhanced delivery of compounds
AssigneesSanford Burnham Prebys Medical Discovery Institute, The Salk Institute for Biological Studies
InventorsLilach Agemy, Dinorah Friedmann-Morvinski, Venkata Ramana Kotamraju, Erkki Ruoslahti, Kazuki Sugahara, Inder Verma
Life of this patent
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Abstract
Disclosed are compositions and methods related to multivalent compositions targeted to cells and tissues. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
Claims31
A composition comprising a surface molecule, one or more homing molecules, and a plurality of membrane perturbing molecules, wherein the one or more homing molecules selectively home to tumor vasculature, and further wherein:
- (i) the one or more of the homing molecules comprise the amino acid sequence CGKRK (SEQ ID NO:1) or a conservative derivative thereof, the amino acid sequence CRKDKC (SEQ ID NO:2) or a conservative derivative thereof, or any combination thereof;
- (ii) the membrane perturbing molecules comprise the amino acid sequence D(KLAKLAK)2 (SEQ ID NO:3) or a conservative variant thereof, (KLAKLAK)2 (SEQ ID NO:3) or a conservative variant thereof, (KLAKKLA)2 (SEQ ID NO:5) or a conservative variant thereof, (KAAKKAA)2 (SEQ ID NO:6) or a conservative variant thereof, or (KLGKKLG)3 (SEQ ID NO:7) or a conservative variant thereof, or any combination thereof.
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Dependencies are inferred from the claim text.