Selective cytopheresis devices and related methods thereof
AssigneesThe Regents of the University of Michigan, CytoPherx, Inc.
InventorsH. David Humes, Deborah Buffington
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Abstract
The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
Claims21
A system for treating leukocytes, the system comprising:
- a device defining a passageway for flowing a biological sample, the passageway comprising a region configured to sequester a leukocyte originating from the sample;
- and
- an agent capable of inhibiting release of a pro-inflammatory substance from the leukocyte or deactivating the leukocyte.
A method for processing a leukocyte contained within a body fluid, the method comprising:
- (a) sequestering extracorporeally a primed or activated leukocyte;
- and
- (b) treating the leukocyte to inhibit release of a pro-inflammatory substance or to deactivate the leukocyte.
A method for treating a subject at risk of developing or having an inflammatory condition, the method comprising:
- (a) sequestering extracorporeally a primed or activated leukocyte from the subject;
- and
- (b) treating the leukocyte to reduce the risk of developing inflammation associated with the inflammatory condition or to alleviate inflammation associated with the inflammatory condition.
21-42. (canceled)
Dependencies are inferred from the claim text.