Methods of treating testosterone deficiency

A method of treating chronic testosterone deficiency in a subject in need thereof comprising the steps of:

• a. administering daily to the subject a dose of an oral pharmaceutical composition comprising:
• i. 15 percent by weight of solubilized testosterone undecanoate;
• ii. 16 percent by weight of polyoxyethylene (40) hydrogenated castor oil;
• iii. 63 percent by weight of glyceryl monolinoleate;
• and
• iv. 6 percent by weight of polyethylene glycol 8000;
• b. measuring the serum testosterone concentration in the subject, wherein said measurement of serum testosterone concentration is made from two to six hours after one of a series of repeated doses of said oral pharmaceutical composition comprising a testosterone ester solubilized in a carrier comprising at least one lipophilic surfactant and at least one hydrophilic surfactant;
• and
• c. increasing the dose of testosterone ester administered in step a. when the measured serum testosterone concentration in the subject is less than about 250 ng/dL, decreasing each dose of testosterone ester administered in step a. when the measured serum testosterone concentration in the subject is greater than about 700 ng/dL, and maintaining each dose of testosterone ester administered in step a. when the measured serum testosterone concentration in the subject is between about 250 ng/dL and about 700 ng/dL;
• wherein steps a.-c. are repeated until the serum testosterone concentration in the subject is between about 250 and about 700 ng/dL;
• and
• wherein the serum testosterone concentration is measured after seven days of daily treatment with the oral pharmaceutical composition.