Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance

A compound of the formula:

• wherein:
• R1 and R2 are each independently selected from hydrogen, halo, hydroxy, amino, mercapto, alkoxy(C≦12), substituted alkoxy(C≦12), or
• wherein n is 1-20 and R3 is hydrogen, alkyl(C≦6), or substituted alkyl(C≦6), or a platinum(IV) chelating group;
• A1 and A2 are each independently selected from hydrogen, halo, hydroxy, alkyl(C≦12), substituted alkyl(C≦12), alkoxy(C≦12), substituted alkoxy(C≦12), or
• wherein n is 1-20 and R3 is hydrogen, alkyl(C≦6), or substituted alkyl(C≦6), or a platinum(IV) chelating group;
• Y1, Y2, Y3, and Y4 are each independently selected from hydrogen, halo, alkyl(C≦12), aryl(C≦12), substituted alkyl(C≦12), or substituted aryl(C≦12);
• X1, X2, X3, X4, X5, and X6 are each independently selected from hydrogen, hydroxy, halo, amino, carboxy, nitro, or cyano,
• alkyl(C≦12), alkenyl(C≦12), alkynyl(C≦12), aryl(C≦12), aralkyl(C≦12), acyl(C≦12), amido(C≦12), or a substituted version of any of these groups, or
• a platinum(IV) chelating group;
• provided that at least one of X1, X2, X3, X4, X5, and X6 is a platinum(IV) chelating group;
• or an oxidized metal complex, a pharmaceutically acceptable salt, organometallic isomer, or tautomer thereof.