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US 2017/0246181 A1Published application
Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
AssigneeBioAxone BioSciences, Inc.
InventorsKenneth M. Rosen, Steven Wayne Riesinger, Lisa McKerracher, Lisa Bond Mortiz
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Abstract
Provided are methods of treating a cerebral cavernous malformation (CCM) and methods of treating cerebral aneurysm in a mammal with certain rho kinase inhibitors.
Claims16
A method of treating a cerebral cavernous malformation (CCM) in a mammal, comprising:
- administering to the mammal a therapeutically effective amount of a pharmaceutical formulation comprising a rho kinase inhibitor selective for ROCK2;
- and
- detecting a reduction in the number or size of CCM lesions and/or maturation of simple CCM lesions into complex, clinically significant lesions relative to the number, size, and/or maturity of CCM lesions before administration.
A method of treating a cerebral aneurysm in a mammal, comprising:
- administering to the mammal a therapeutically effective amount of a pharmaceutical formulation comprising a rho kinase inhibitor selective for ROCK2;
- and
- detecting a reduction in the number or the size of cerebral aneurysms and/or a reduction in the maturation of simple aneurysms into complex, clinically significant aneurysms relative to the number, size and/or maturity of the cerebral aneurysms before administration.
Dependencies are inferred from the claim text.