Use of cdk9 inhibitors to reduce cartilage degradation
AssigneeThe Regents of the University of California
InventorsDominik HAUDENSCHILD, Paul Di CESARE, Jasper YIK, Blaine CHRISTIANSEN
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Abstract
The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
Claims23
A method of reducing, preventing or inhibiting cartilage degradation and/or chondrocyte death in a subject in need thereof, comprising administering to the subject an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9), thereby reducing, preventing or inhibiting cartilage degradation and/or chondrocyte death in the subject.
A method of reducing, preventing, delaying or inhibiting the onset and/or progression of post-traumatic osteoarthritis in a subject in need thereof, comprising administering to the subject an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9), thereby reducing, preventing or inhibiting post-traumatic osteoarthritis in the subject.
(canceled)
A method of reducing, preventing or inhibiting degradation of an osteochondral explant and/or reducing, preventing or inhibiting chondrocyte death during storage, comprising storing the osteochondral explant and/or chondrocytes in a solution comprising an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9).
19-22. (canceled)
A composition comprising an osteochondral explant in a solution comprising an inhibitor of cyclin-dependent kinase 9 (CDK9).
24-27. (canceled)
Dependencies are inferred from the claim text.