Compositions and methods for selectively depleting senescent cells

A compound, the compound comprising Formula (II):

• wherein:
• X is selected from the group consisting of C(O), C(S), C(NH) and S(O)2;
• Y is selected from the group consisting of O, NH and S;
• n is an integer from 0-4;
• R1, R2, R3, R4, R5, R6, R7, and R8 are each independently selected from the group consisting of hydrogen, deuterium, halogen, CF3, CN, OH, OCH3, OR, SR, NRR, NRCOR, NRCONRR, NRCO2R, COR, CO2R, NOR, NO2, CONRR, OC(O)NRR, SO2R, SO2NRR, NRSO2R, NRSO2NRR, C(O)C(O)R, and C(O)CH2C(O)R, a substituted or unsubstituted C1 to C6 alkyl, a substituted or unsubstituted C1 to C6 alkenyl, a substituted or unsubstituted C1 to C6 alkynyl, a substituted or unsubstituted aryl, and a substituted or unsubstituted heteroaryl;
• R is independently selected from the group consisting of hydrogen, substituted C1-C4 aliphatic moiety, aliphatic moiety containing nitrogen, oxygen, or sulfur, or alternately, two R moieties bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3-7 membered saturated or unsaturated ring having 1-2 additional heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur;
• Optionally, R1 and R2, R2 and R3, R3 and R4, R4 and R5, R5 and R6, R6 and R7, or R7 and R8 are taken together to form a 4-8 membered saturated or unsaturated ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur;
• A is selected from the group consisting of
• wherein:
• R9 and R10 are independently selected from the group consisting of hydrogen, deuterium, halogen, CF3, CN, OH, OCH3, OR, SR, NRR, NRCOR, NRCONRR, NRCO2R, COR, CO2R, NOR, NO2, CONRR, OC(O)NRR, SO2R, SO2NRR, NRSO2R, NRSO2NRR, C(O)C(O)R, and C(O)CH2C(O)R, a substituted or unsubstituted C1 to C6 alkyl, a substituted or unsubstituted C1 to C6 alkenyl, a substituted or unsubstituted C1 to C6 alkynyl, a substituted or unsubstituted aryl, and a substituted or unsubstituted heteroaryl;
• R is independently selected from the group consisting of hydrogen, substituted C1-C4 aliphatic moiety, aliphatic moiety containing nitrogen, oxygen, or sulfur, or alternately, two R moieties bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3-7 membered saturated or unsaturated ring having 1-2 additional heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur;
• Optionally, R9 and R10 are taken together to form a 5-8 membered saturated or unsaturated ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur;
• B is
• wherein:
• R11, R12, R13, R14, and R15 are each independently selected from the group consisting of hydrogen, deuterium, halogen, CF3, CN, OH, OCH3, OR, SR, NRR, NRCOR, NRCONRR, NRCO2R, COR, CO2R, NOR, NO2, CONRR, OC(O)NRR, SO2R, SO2NRR, NRSO2R, NRSO2NRR, C(O)C(O)R, and C(O)CH2C(O)R, a substituted or unsubstituted C1 to C6 alkyl, a substituted or unsubstituted C1 to C6 alkenyl, a substituted or unsubstituted C1 to C6 alkynyl, a substituted or unsubstituted aryl, and a substituted or unsubstituted heteroaryl;
• R is independently selected from the group consisting of hydrogen, substituted C1-C4 aliphatic moiety, aliphatic moiety containing nitrogen, oxygen, or sulfur, or alternately, two R moieties bound to the same nitrogen atom are optionally taken together with the nitrogen atom to form a 3-7 membered saturated or unsaturated ring having 1-2 additional heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur;
• Optionally, R11 and R12, R12 and R13, R13 and R14, and R14 and R15 are taken together to form a 4-8 membered saturated or unsaturated ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur;
• m is an integer from 0-6;
• Optionally, the phenyl ring in B can be replaced by the following one or more monocyclic aryl, one or more heteroaryl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, an 8-10 membered bicyclic saturated, partially unsaturated or aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from the group consisting of nitrogen, oxygen or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from the group consisting of nitrogen, oxygen, or sulfur.