B- AND y -DIKETONES AND y -HYDROXYKETONES AS WNT/ B -CATENIN SIGNALING PATHWAY ACTIVATORS

A method for promoting healing of bone fractures, bone defects, craniofacial defects, otosclerosis or osteogenesis imperfecta in a subject, the method comprising administering to the subject a compound of Formula I, or a pharmaceutically acceptable salt thereof:

• wherein R1 is a substituted or unsubstituted heteroaryl, wherein the heteroaryl is selected from the group consisting of
• with the proviso that a carbon atom of the R1 heteroaryl is attached to the carbonyl;
• R2 is selected from the group consisting of a substituted or unsubstituted
• and a substituted or unsubstituted aryl, wherein the aryl is selected from phenyl or naphthyl;
• and
• R3, R4, R5 and R6 are H.

A method of treating osteoporosis in a subject, the method comprising administering to the subject a compound of Formula I, or a pharmaceutically acceptable salt thereof:

• wherein R1 is a substituted or unsubstituted heteroaryl, wherein the heteroaryl is selected from the group consisting of
• with the proviso that a carbon atom of the R1 heteroaryl is attached to the carbonyl;
• R2 is selected from the group consisting of a substituted or unsubstituted
• and a substituted or unsubstituted aryl, wherein the aryl is selected from phenyl or naphthyl;
• and
• R3, R4, R5 and R6 are H.

A method for treating a bone condition in a subject, wherein the bone condition is selected from the group consisting of childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, osteotomy, and bone loss associated with periodontitis, the method comprising administering to the subject a compound of Formula I, or a pharmaceutically acceptable salt thereof:

• wherein R1 is a substituted or unsubstituted heteroaryl, wherein the heteroaryl is selected from the group consisting of
• with the proviso that a carbon atom of the R1 heteroaryl is attached to the carbonyl;
• R2 is selected from the group consisting of a substituted or unsubstituted
• and a substituted or unsubstituted aryl, wherein the aryl is selected from phenyl or naphthyl;
• and
• R3, R4, R5 and R6 are H.