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AssigneeOmeros Corporation
InventorsGregory A. Demopulos, Pamela Pierce Palmer, Jeffrey M. Herz
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A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that demonstrates substantial agonist activity at alpha adrenergic receptors and that is selected for peripheral (local) vasoconstriction and one or more additional pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for peripheral vasoconstriction and inhibition of pain and/or inflammation while avoiding undesirable side effects associated with systemic application of larger doses of the agents.
A method of inhibiting pain and inflammation at a joint during an arthroscopic surgical procedure, comprising delivering to a joint during an arthroscopic procedure a solution comprising:
A method of inhibiting pain and inflammation at a joint of an extremity during an arthroscopic or open surgical procedure or other extremity procedure, comprising delivering to the surgical site during the procedure a solution comprising:
A method of inhibiting pain and inflammation at a surgical or operative/procedural sites during an oral/dental surgery, ocular surgery or burn treatment procedures, comprising delivering to a site during an oral/dental surgery, ocular surgery or burn treatment procedure a solution comprising:
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