Methods and Compositions for Treating Psychotic Disorders
AssigneeSound Pharmaceuticals Incorporated
InventorJonathan Kil
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Abstract
Disclosed herein are novel drug combinations comprising a glutathione peroxidase (GPx) mimic compound and an antipsychotic agent, pharmaceutical compositions comprising one or more of such combinations, methods of preparing pharmaceutical compositions comprising one or more such combinations, and methods of treatment, prevention, inhibition or amelioration of one or more diseases associated with GPx mediated disorders, psychotic disorders or complications from administering an antipsychotic agent at high dose or long term using such combination or pharmaceutical compositions. Furthermore, a method is disclosed for reducing the anti-psychotic agent's dosages that comprises co-administering a therapeutically effective amount of a glutathione peroxidase mimic compound.
Claims21
A method of reducing the dose of an administered antipsychotic agent for treating psychotic disorders, comprising co-administering a therapeutically effective amount of a glutathione peroxidase modulator compound, wherein an effective dosage of the antipsychotic compound in the presence of the co-administered glutathione peroxidase modulator compound is lower than an effective dose of the antipsychotic compound in the absence of the glutathione peroxidase modulator compound.
A method of treating psychotic disorders, administering a drug combination that comprises a therapeutically effective amount of a glutathione peroxidase modulator compound and an antipsychotic agent.
A method of reducing a side effect of administering an antipsychotic agent for treating psychotic disorders, comprising co-administering a therapeutically effective amount of a glutathione peroxidase modulator compound.
A pharmaceutical composition comprising a combination of therapeutic agents, said combination consisting of:
- (1) a glutathione peroxidase modulator compound or a pharmaceutically acceptable salt thereof;
- and
- (ii) an antipsychotic agent or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.