Novel d3 dopamine receptor agonists to treat dyskinesia in parkinson's disease
AssigneesDrexel University, Rutgers, The State University of New Jersey
InventorsSandhya KORTAGERE, Eldo V. KUZHIKANDAHIL
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Abstract
The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
Claims4
A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier and at least one compound of formula (I):
- wherein:
- R1 is selected from the group consisting of H and halo,
- wherein R1 is ortho to the
- substituent;
- R2 is selected from the group consisting of H and halo,
- wherein R2 is para to the
- substituent;
- with the proviso that R1 and R2 are not simultaneously H;
- R3 is selected from the group consisting of H, cyano, halo, nitro, C1-6 alkyl, heteroalkyl, carboxy, alkylcarboxy, formyl, and alkyl-carbonyl;
- R4 is selected from the group consisting of H and C1-3 alkyl;
- R5 is selected from the group consisting of H, C1-3 alkyl, substituted C1-3 alkyl, and heteroalkyl;
- and,
- n is 2;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.