Controlled dose drug delivery system
AssigneeShire LLC
InventorsAMIR SHOJAEI, STEPHANIE READ, RICHARD A. COUCH, PAUL HODGKINS
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Abstract
A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising a pharmaceutically active amphetamine salt covered with an immediate-release coating and a pharmaceutically active amphetamine salt covered with an enteric coating wherein the immediate release coating and the enteric coating provide for multiple pulsed dose delivery of the pharmaceutically active amphetamine salt. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.
Claims22
1-32. (canceled)
A pharmaceutical composition comprising:
- at least one amphetamine salt and a pharmaceutically acceptable carrier;
- wherein the composition provides an about bioequivalent plasma level of amphetamine in a patient compared to an equivalent amount of at least one amphetamine salt contained in the combination of ADDERALL® and an immediate release amphetamine salt composition when the immediate release composition is administered to the patient about 8 hours after the ADDERALL®.
(canceled)
A sustained release pharmaceutical composition comprising:
- (a) at least one amphetamine salt,
- (b) a sustained release coating, and
- (c) a delayed release coating,
- wherein the at least one amphetamine salt is released about 4 to about 6 hours after oral administration to a patient.
53-58. (canceled)
Dependencies are inferred from the claim text.