Compositions and methods for transdermal delivery of amphetamine
AssigneeNoven Pharmaceuticals, Inc.
InventorRobert L. Lambert
Life of this patent
Estimating the term…
Abstract
Compositions for the transdermal delivery of amphetamine in a flexible, finite form are described. The compositions comprise a polymer matrix that includes amphetamine or a pharmaceutically acceptable salt or prodrug thereof and a backing layer comprising a polyurethane film layer and a polyester film layer, with a polyurethane adhesive disposed therebetween. Related methods also are described. Also described are compositions that exhibit a short onset period and a long duration of therapeutic effect
Claims23
-25. (canceled)
A method of making a composition for the transdermal delivery of amphetamine in the form of a flexible finite system for topical application, comprising combining (i) a polymer matrix comprising amphetamine or a pharmaceutically acceptable salt or prodrug thereof and (ii) a backing layer comprising (a) a polyurethane film layer and (b) a polyester film layer, wherein a polyurethane adhesive is disposed between the polyurethane film layer and the polyester film layer, wherein the polyurethane film layer of the backing layer is adjacent the polymer matrix.
A composition for the transdermal delivery of amphetamine in the form of a flexible finite system for topical application, made by a method comprising
- (i) applying to a release liner a polymer matrix comprising amphetamine or a pharmaceutically acceptable salt or prodrug thereof and drying the polymer matrix, and
- (ii) applying to the polymer matrix a backing layer comprising (a) a polyurethane film layer and (b) a polyester film layer, wherein a polyurethane adhesive is disposed between the polyurethane film layer and the polyester film layer, wherein the polyurethane film layer of the backing layer is adjacent the polymer matrix.
Dependencies are inferred from the claim text.