Oxidized cellulose microspheres
AssigneeCovidien LP
InventorsPhillip Blaskovich, Rachit Ohri, Lan Pham
Life of this patent
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Abstract
A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
Claims21
1-20. (canceled)
A process for forming microspheres comprising:
- forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;
- contacting the first plurality of microspheres with a solution of a biodegradable polymer to form a discontinuous phase liquid;
- contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion;
- and
- extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in the biodegradable polymer.
A process for forming microspheres comprising:
- forming a first plurality microspheres including a biodegradable polymer;
- contacting the first plurality of microspheres with an oxidized cellulose solution to form a discontinuous phase liquid;
- contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion;
- and
- extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in oxidized cellulose.
A microsphere comprising:
- a first biodegradable polymer encapsulating at least one additional microsphere, the at least one additional microsphere including a second biodegradable polymer and at least one bioactive agent, wherein the first biodegradable polymer and the second biodegradable polymer are different and at least one of the first biodegradable polymer or the second biodegradable polymer is oxidized cellulose.
Dependencies are inferred from the claim text.