Phospholipid depot
OwnerHailiang CHEN, Andrew Xian CHEN +2inventors
InventorsHailiang CHEN, Andrew Xian CHEN, Dushyanth SURAKANTI, Franklin OKUMU
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Abstract
The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.
Claims35
A depot composition comprising:
- at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, and pharmaceutically acceptable salts thereof;
- water;
- a phospholipid;
- an oil;
- and a viscosity modifying agent;
- wherein said composition is characterized by a major endothermic event up to about 100° C.
A depot composition comprising:
- at least one hydrophilic water-soluble pharmaceutically active agent selected from group consisting of vancomycin, gentamicin, and pharmaceutically acceptable salts thereof;
- water;
- a phospholipid;
- an oil;
- and a viscosity modifying agent;
- wherein said composition releases no more than about 80% of vancomycin and/or gentamicin at two hours when measured in accordance with a USP method I using 500 ml of deionized water as a medium.
A composition comprising:
- at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, and pharmaceutically acceptable salts thereof;
- water;
- a phospholipid;
- an oil;
- and a viscosity modifying agent;
- wherein said composition is selected from an emulsion, a primary emulsion, a nanoemulsion, a solution, dry paste, a gel, or a combination thereof.
A composition comprising:
- vancomycin or pharmaceutically acceptable salts thereof;
- water;
- a phospholipid;
- an oil;
- and a viscosity modifying agent;
- wherein said composition is an oil-in-water emulsion having an initial drug concentration of vancomycin in water from about 1 mg/ml to about 50 mg/ml.
A composition comprising:
- gentamicin or pharmaceutically acceptable salts thereof;
- water;
- a phospholipid;
- an oil;
- and a viscosity modifying agent;
- wherein said composition is oil-in-water emulsion having an initial drug concentration of gentamicin in water from about 1 mg/ml to about 75 mg/ml.
A method of administering a depot comprising:
- administering intradermally, intramuscularly, intraincisionally, subcutaneously, by instillation or topically to a wound at least one hydrophilic water-soluble pharmaceutically active agent selected from group consisting of vancomycin, gentamicin, and pharmaceutically acceptable salts thereof;
- water;
- a phospholipid;
- an oil;
- and a viscosity modifying agent.
Dependencies are inferred from the claim text.