Methods, compositions, and devices for supplying dietary fatty acid needs
AssigneeAlcresta Therapeutics, Inc.
InventorsAlexey L. MARGOLIN, Robert GALLOTTO, Bhami Shenoy
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Abstract
Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.
Claims27
1-89. (canceled)
A method of providing a nutritional formula to a patient, the method comprising:
- receiving a nutritional composition within an enteral feeding device, the enteral feeding device comprising:
- a container defining an interior for receiving the nutritional composition;
- an opening fluidly connected to the container, wherein the opening is dimensioned for connection to a feeding tube;
- a structure in fluid communication with the interior of the container;
- and
- a lipase immobilized by covalent binding to the structure;
- exposing the nutritional composition to the lipase when the nutritional composition is received within the container to hydrolyze long-chain polyunsaturated fatty acid (LC-PUFA) triglycerides and/or LC-PUFA esters within the nutritional composition into monoglycerides and free fatty acids to form the nutritional formula;
- delivering the nutritional formula out of the opening of the enteral feeding device and into a feeding tube;
- and
- providing the nutritional formula to the patient via the feeding tube.
A method of providing a nutritional formula to a patient, the method comprising:
- passing a nutritional composition comprising long-chain polyunsaturated fatty acid (LC-PUFA) triglycerides into a fluid inlet of an enteral feeding device;
- exposing the nutritional composition to lipase immobilized by covalent binding to a plurality of particles within the enteral feeding device, wherein exposing the nutritional composition to the lipase hydrolyzes at least some of the LC-PUFA triglycerides to form monoglycerides and free fatty acids to create the nutritional formula;
- delivering the nutritional formula out of a fluid outlet of the enteral feeding device and into a feeding tube;
- and
- providing the nutritional formula to the patient via the feeding tube.
A method of providing a nutritional formula to a patient, the method comprising
- receiving a nutritional composition comprising long-chain polyunsaturated fatty acid (LC-PUFA) triglycerides within an enteral feeding device;
- exposing the nutritional composition to lipase immobilized by covalent binding to a plurality of particles within the enteral feeding device;
- retaining the immobilized lipase within the enteral feeding device so that no more than 0.1 milligram of lipase per milligram of LC-PUFA is delivered from the enteral feeding device;
- and
- delivering the nutritional formula from the enteral feeding device to the patient via a feeding tube.
Dependencies are inferred from the claim text.