Implantable bioreactor for delivery of paracrine factors

An intravascular implantable bioreactor, comprising:

• a pouch;
• and
• cells enclosed within the pouch, said cells being capable of producing paracrine factors,
• wherein the pouch is collapsible and expandable to be intravascularly implantable, wherein the pouch is semipermeable such that it provides containment of the cells,
• preventing the egress of the cells while further providing a barrier that shields the cells from immunological attack, and
• wherein the pouch comprises multiple pores having a diameter of at least about 0.1 μm, such that the pores are capable of releasing out of the pouch paracrine factors that enhance recovery of injured tissue.