Prophylaxis of colorectal and gastrointestinal cancer
AssigneesLes Laboratoires Servier, Institut National De La Sante Et De La Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS)
InventorsLeila HOUHOU, Mathieu PETREMANN, Dominique JOUBERT, Frédéric HOLLANDE
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Abstract
The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having pre-cancerous adenomatous polyps. The present disclosure provides compositions comprising anti-PG antibodies suitable for use in the methods of the disclosure. The present disclosure also provides methods and compositions useful for monitoring the efficacy of anti-PG treatment in subjects with pre-cancerous polyps.
Claims25
A method of preventing gastrointestinal cancer in a human subject, comprising ministering to a human subject predisposed to develop adenomatous polyps an amount of an anti-PG antibody sufficient to provide a therapeutic benefit.
A method of identifying a subject in need of colonoscopy comprising determining whether a subject predisposed to develop adenomatous polyps has a plasma or serum progastrin concentration at or above about 50 pM, where such a concentration in said subject is indicative of a need for follow-up colonoscopy.
A method of identifying a subject with increased probability of having adenomatous polyps comprising determining the level of PG in samples of a body fluid from a subject predisposed to develop adenomatous polyps, and comparing the level of PG in the sample to a baseline, wherein a level of PG in the sample above the baseline level is indicative of a need for anti-progastrin treatment.
A method of monitoring the effectiveness of anti-PG treatment comprising determining whether a subject with adenomatous polyposis has a plasma or serum progastrin concentration below about 10 pM, where such a concentration indicates the treatment is effective.
Dependencies are inferred from the claim text.