Adhesive compositions and patches, and associated systems, kits, and methods
AssigneeXcedeTechnologies, Inc.
InventorsDaniel Grant Ericson, Kyle Robert Brandy
Life of this patent
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Abstract
Adhesive compositions and patches, and associated systems, kits, and methods, are generally described. Certain of the adhesive compositions and patches can be used to treat tissues (e.g., in hemostatic or other tissue treatment applications), according to certain embodiments.
Claims161
A water-activated adhesive article, comprising:
- a substrate;
- and
- a water activated polymeric adhesive disposed within a solvent and in contact with the substrate.
The water-activated adhesive article of any one of claims 1-11, wherein the water-activated polymeric adhesive comprises the adhesive composition of any one of claims 1-18.
A method of applying an adhesive to a substrate, comprising:
- applying an adhesive composition comprising a combination of a water-activated polymeric material and a solvent to a substrate.
An adhesive composition, comprising:
- (1) a first polymeric material comprising one or more monomers of formula (m-1) cross-linked with one or more monomers of formula (m-2);
- and
- (2) a different, second polymeric material comprising one or more monomers of formula (m-1) cross-linked with one or more monomers of formula (m-2);
- wherein:
- X is O or NR1;
- each instance of R1 is independently hydrogen or optionally substituted C1-50alkyl;
- each instance of R2, R3, R4, and R5 is independently hydrogen, optionally substituted C1-4alkyl, or halogen;
- G is optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, optionally substituted heteroaryl, a polymer, or a carbohydrate;
- Y is O or NH;
- p is 0 or 1;
- n is 0 or 1, provided when p is 1, then n is 1;
- and
- m is an integer of 2 or greater.
A patch, comprising a solid matrix comprising fibrin and having a moisture content of less than 20 wt %.
A patch, comprising:
- a solid matrix comprising fibrin,
- wherein the solid matrix is substantially free of thrombin.
A method of making a patch, comprising:
- exposing a solid matrix comprising water and fibrin to a dehydrating agent such that water is removed from the solid matrix.
A method of preparing a solid matrix comprising cross-linked fibrin, comprising:
- applying a compressive force to a liquid containing composition comprising fibrin and/or fibrinogen;
- passing at least a portion of a liquid component of the composition through a filter so that at least a portion of the fibrin and/or fibrinogen is separated from the at least a portion of the liquid component;
- and
- polymerizing the fibrinogen to form fibrin and/or cross-linking the fibrin to form the solid matrix comprising cross-linked fibrin,
- wherein the fibrin and fibrinogen are not exposed to substantial amounts of thrombin during the preparation of the patch.
A method of preparing a solid matrix comprising cross-linked fibrin, comprising:
- applying a compressive force to a liquid containing composition comprising fibrin and/or fibrinogen within a chamber;
- and
- polymerizing the fibrinogen to form fibrin and/or cross-linking the fibrin to form the solid matrix comprising cross-linked fibrin,
- wherein the fibrin and fibrinogen are not exposed to substantial amounts of thrombin during the preparation of the patch.
Dependencies are inferred from the claim text.