Intermediates in the synthesis of cephalosporin compounds
AssigneeMerck Sharp & Dohme Corp.
InventorsKristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Abstract
Described herein are crystalline forms of a compound of formula (III−), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III−): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.
Claims24
A crystalline form of a compound of formula (III′):
- wherein
- X is Cl, Br, or I;
- and
- R1 and R2 are each independently an oxygen protecting group.
A process of making a crystalline form of a compound of formula (III′):
- wherein
- X is Cl, Br, or I;
- and
- R1 and R2 are each independently an oxygen protecting group,
- comprising the step of admixing a non-crystalline form of a compound of formula (III′) and an aromatic solvent to form an admixture comprising the crystalline form of a compound of formula (III′).
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Dependencies are inferred from the claim text.