Controlled-release and stratified cyclodextrin inclusion complex vehicles
AssigneeCzap Reseach and Development, LLC
InventorAl Czap
Life of this patent
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Abstract
The invention provides cyclodextrin inclusion complex delivery vehicles, in which the cyclodextrin inclusion complex is provided together with enzyme having a cyclodextrin-degrading activity capable of digesting the cyclodextrin, so that upon delivery of the vehicle to a target the enzyme is activated and releases the guest molecule from the cyclodextrin cavity. In alternative aspects, these cyclodextrin inclusion complex delivery vehicles are for example provided in the form of medicaments, food ingredients, medical food ingredients, nutritional supplement ingredients, dietary supplement ingredients, herbicides, insecticides, fungicides, animal repellents, pheromones, plant growth regulators, fragrances, fabrics or packaging materials.
Claims28
A cyclodextrin inclusion complex delivery vehicle, comprising:
- a cyclodextrin having a cavity;
- a biologically active molecule that is at least partially retained as a guest molecule within the cavity of the cyclodextrin, forming a cyclodextrin inclusion complex;
- a biologically acceptable carrier for the cyclodextrin inclusion complex, wherein the guest molecule is stably retained by the cyclodextrin within the biologically acceptable carrier;
- and,
- an enzyme having a cyclodextrin-degrading activity capable of digesting the cyclodextrin retaining the guest molecule, wherein the enzyme is formulated so that the cyclodextrin-degrading activity is activated on delivery of the vehicle to a target so as to release the guest molecule from the cyclodextrin cavity.
A method of formulating a cyclodextrin inclusion complex delivery vehicle, comprising:
- providing a cyclodextrin having a cavity;
- providing biologically active molecule that is at least partially retained as a guest molecule within the cavity of the cyclodextrin, forming a cyclodextrin inclusion complex;
- providing a biologically acceptable carrier for the cyclodextrin inclusion complex, wherein the guest molecule is stably retained by the cyclodextrin within the biologically acceptable carrier;
- and,
- providing an enzyme having a cyclodextrin-degrading activity capable of digesting the cyclodextrin retaining the guest molecule, wherein the enzyme is co-formulated with the cyclodextrin inclusion complex so that the cyclodextrin-degrading activity is activated on delivery of the vehicle to a target so as to release the guest molecule from the cyclodextrin cavity.
A stratified cyclodextrin inclusion complex delivery vehicle, comprising:
- a first cyclodextrin having a cavity;
- a first biologically active molecule that is at least partially retained as a first guest molecule within the cavity of the first cyclodextrin, forming a first cyclodextrin inclusion complex;
- a second cyclodextrin having a cavity;
- a second biologically active molecule that is at least partially retained as a second guest molecule within the cavity of the second cyclodextrin, forming a second cyclodextrin inclusion complex;
- a biologically acceptable carrier for the cyclodextrin inclusion complexes, wherein the first guest molecule is more stably retained by the first cyclodextrin, compared to an inclusion complex of the first guest molecule and the second cyclodextrin, within the biologically acceptable carrier.
A method of forming a stratified cyclodextrin inclusion complex delivery vehicle, comprising:
- providing a first cyclodextrin having a cavity;
- providing a first biologically active molecule that is at least partially retained as a first guest molecule within the cavity of the first cyclodextrin, forming a first cyclodextrin inclusion complex;
- providing a second cyclodextrin having a cavity;
- providing a second biologically active molecule that is at least partially retained as a second guest molecule within the cavity of the second cyclodextrin, forming a second cyclodextrin inclusion complex;
- providing a biologically acceptable carrier for the cyclodextrin inclusion complexes, wherein the first guest molecule is more stably retained by the first cyclodextrin, compared to an inclusion complex of the first guest molecule and the second cyclodextrin, within the biologically acceptable carrier.
Dependencies are inferred from the claim text.