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US 2017/0224821 A1Published application
Ionizing-radiation-responsive compositions, methods, and systems
OwnerEdward S. Boyden, Roderick A. Hyde +8inventors
InventorsEDWARD S. BOYDEN, RODERICK A. HYDE, MURIEL Y. ISHIKAWA, EDWARD K.Y. JUNG, JORDIN T. KARE, NATHAN P. MYHRVOLD, CLARENCE T. TEGREENE, THOMAS ALLAN WEAVER, LOWELL L. WOOD, JR., VICTORIA Y.H. WOOD
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Abstract
A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.
Claims5
1-142. (canceled)
A method, comprising:
- delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including:
- a luminescent material, the luminescent material being responsive to ionizing radiation in at least one ionizing radiation energy band to produce optical energy in at least one optical wavelength band;
- a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band;
- and
- a matrix material disposed to at least partially sustain proximity of the luminescent material and the photosensitive biologically active material;
- and
- irradiating at least a portion of the at least one region with ionizing radiation in the at least one ionizing radiation energy band.
4 more elements
A method, comprising:
- delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including:
- a luminescent material, the luminescent material being responsive to ionizing radiation in at least one ionizing radiation energy band to produce optical energy in at least one optical wavelength band;
- a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band;
- and
- an optically-inhibiting material disposed to at least partially block coupling of optical energy in the at least one optical wavelength band to the photosensitive biologically active material;
- and
- irradiating at least a portion of the at least one region with ionizing radiation in the at least one ionizing radiation energy band.
4 more elements
A method, comprising:
- delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including:
- a luminescent material, the luminescent material being responsive to ionizing radiation in at least one ionizing radiation energy band to produce optical energy in at least one optical wavelength band;
- a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band;
- and
- a coating material of a type selected to adjust at least one of the solubility, durability, suspension stability, bioactivity, biocompatibility, and non-toxicity of the ionizing-radiation-responsive composition;
- and
- irradiating at least a portion of the at least one region with ionizing radiation in the at least one ionizing radiation energy band.
4 more elements
146-214. (canceled)
Dependencies are inferred from the claim text.