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US 2017/0218088 A1Published application
Methods for treating and diagnosing disease
AssigneeThe University of Valencia
InventorsJuan Saus, Fernando Revert, Ramón Merino Pérez, Jesús Merino Pérez, Francisco Revert-Ros
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Abstract
The present invention provides methods for the diagnosis and/or treatment of chronic kidney disease, immune complex-mediated GN, rheumatoid arthritis, and pulmonary fibrosis, and methods for identifying compounds for such therapeutic use.
Claims16
A method for treating pulmonary fibrosis (PF), comprising administering to a subject in need thereof an amount effective of an inhibitor of 77 kD GPBP to treat the PF.
A method for diagnosing pulmonary fibrosis (PF) comprising
- (a) contacting a plasma sample from a subject at risk of PF with a GPBP-binding molecule that binds to 77 kD GPBP under conditions to promote selective binding of the GPBP-binding molecule to the 77-kD GPBP;
- (b) detecting complex formation between the GPBP-binding molecule and the 77 kD GPBP in the plasma sample;
- (c) comparing an amount of complex formed between the GPBP-binding molecule and the 77 kD GPBP in the plasma sample to control;
- and
- (d) diagnosing the subject as having PF based on the comparison, or providing the comparison to an entity for diagnosis of PF.
2 more elements
Dependencies are inferred from the claim text.