Synthetic analogues of neural regeneration peptides
AssigneeCuronz Holdings Company Limited
InventorsPaul William Richard Harris, Margaret Anne Brimble, Frank Sieg
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Abstract
Embodiments of this invention include synthetic compounds (NRP analogues) of peptides termed neural regeneration peptides (NRPs). NRP analogues are made by substituting amino acids in the native peptide sequence, modifying amino acids chemically, by replacing amino acids with synthetic moieties, by stabilizing β-turns, acetylation of terminal glycine residues or by cyclization. NRP analogues can be used to treat a variety of conditions involving degeneration of neural cells, and includes treating disorders of the nervous system, including peripheral neuropathy, multiple sclerosis, diabetic peripheral neuropathy, neurotoxin-induced neurodegeneration, and amyotrophic lateral sclerosis.
Claims18
A neural regeneration peptide (NRP) compound selected from the group comprising the sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 and SEQ ID NO:11.
A synthetic NRP compound, wherein said compound is produced from a NRP by modifying a β-turn, a peptide domain APGR, a peptide domain RAGG, a replacement of a glycine residue with asparagine, replacement of an L-amino acid by a D-amino acid, or cyclization of said NRP.
Dependencies are inferred from the claim text.