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US 2017/0212077 A1Published application
Methods of isotachophoresis detection
AssigneeTechnion Research & Development Foundation Limited
InventorsMoran BERCOVICI, Merav KARSENTY, Tally ROSENFELD
Life of this patent
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Abstract
An isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the detection and/or separation of analytes of interest.
Claims21
-36. (canceled)
An isotachophoresis (ITP) apparatus comprising:
- (a) a flow channel comprising at least one first cross-section area and at least one second cross-section area, wherein the ratio between said at least one second cross-section area and said at least one first cross-section area is of 1:2-1:50;
- (b) a first zone and a second zone, said first zone is configured to contain a solution of high effective mobility leading electrolyte (LE) ion, and said second zone is configured to contain a solution of low effective mobility trailing electrolyte (TE) ion;
- and
- (c) a control unit configured to modulate an ITP interface in response to a significant electric current or voltage change;
- optionally
- wherein said flow channel is configured to be operably connected to at least one anode and at least one cathode.
3 more elements
A system comprising:
- (i) an ITP apparatus comprising:
- (a) a flow channel comprising at least one first cross-section area and at least one second cross-section area, wherein the ratio between said at least one second cross-section area and said at least one first cross-section area is of 1:2-1:50, and
- (b) a first zone and a second zone, said first zone is configured to contain a solution of high effective mobility leading electrolyte (LE) ion, and said second zone is configured to contain a solution of low effective mobility trailing electrolyte (TE) ion;
- and
- (ii) a measurement apparatus configured to measure electric current or voltage;
- and
- (iii) a control unit configured to modulate an ITP interface of said ITP apparatus in response to a significant electric current or voltage change;
- optionally
- wherein said flow channel is configured to be operably connected to at least one anode and at least one cathode.
6 more elements
A kit comprising:
- (i) the ITP apparatus of claim 1;
- (ii) a solution of high effective mobility leading electrolyte (LE) ion;
- and
- (iii) a solution of low effective mobility trailing electrolyte (TE) ion;
- optionally
- (iv) comprising instruction for use of said kit.
3 more elements
A computer program product comprising a non-transitory computer-readable storage medium having program code embodied thereon, the program code executable by at least one hardware processor to:
- (a) detect a significant electric current or voltage change in a flow channel comprising at least one first cross-section area and at least one second cross-section area, wherein the ratio between said at least one second cross-section area and said at least one first cross-section area is of 1:2-1:50;
- and
- (b) perform at least one function in response to the significant electric current or voltage change detected in step (a).
Dependencies are inferred from the claim text.