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US 2017/0209589 A1Published application
Novel conjugation reagents
AssigneePolytherics Limited
InventorsAntony Robert GODWIN, Stephen James BROCCHINI
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Abstract
The invention provides compound of the general formula: in which each X independently represents a polymer chain; n represents an integer greater than 1; Q represents a linker; Y represents an amide group; and Z represents either —CH.(CH2L)2 or —C(CH2L)(═CH2), in which each L independently represents a leaving group. The compounds are useful reagents for the conjugation of polymers to proteins, the resulting conjugates being novel and also forming part of the invention.
Claims17
A compound of general formula (I):
- in which Q is:
- in which each X independently represents a polymer chain;
- A represent a group CO, CHOH, CH.NH2, CH.NHR, CH.NR2, CH.OR CH.O.C(O)R, CH.NHC(O)R, or CH.N(C(O)R)2, in which each R represents a hydrogen atom or an alkyl, aryl or alkyl-aryl group;
- and either each of Pr and Pr2 represents a separate protein or peptide molecule or both of Pr1 and Pr2 together represent a single protein or peptide bonded at two separate points.
1 more element
Dependencies are inferred from the claim text.