Carbon Nanotube Compositions and Methods of Use Thereof
AssigneeYale University
InventorsTarek M. Fahmy, Lisa D. Pfefferle, Gary L. Haller
Life of this patent
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Abstract
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.
Claims5
-17. (canceled)
A method for adoptive immunotherapy of a disease or disorder characterized by over-activation, undesirable or aberrant activation of an immune response comprising
- isolating a population of CD4+CD45+ T cells from a subject to be treated,
- activating a population of CD4+CD45+ T cells isolated from a subject with a nanotube particle composite comprising carbon nanotubes, the nanotubes having bound to or present on the surface one or more T cell receptor activators and nanoparticles comprising an immunostimulatory agent,
- expanding the CD4+CD45+ T cells, and
- administering the CD4+CD45+ T cells to the subject to be treated in an amount effective to eliminate or reduce the risk or delay the outset of conditions associated with undesirable activation, over-activation or inappropriate or aberrant activation of an immune response.
-22. (canceled)
Dependencies are inferred from the claim text.