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US 2017/0198003 A1Published application
Defined enzymatic synthesis of lipid a analogs
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsXirui Xiao, Chaitan Khosla
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Abstract
Provided herein include methods and compositions for synthesis of Lipid IVA and derivatives thereof, using a defined set of pathway enzyme, which may be isolated and used to reconstitute all or part of the pathway in a cell-free reaction.
Claims21
A composition comprising an isolated compound having the structure of Formula I:
- (a) wherein M1, M2, M3, M4 each are independently NH or O;
- at least one of R1, R2, R3, R4 is selected, independently, from the following structure:
- wherein each X, Y, Z, X1, Y1, Z1, X2, Y2, Z2, X3, Y3, X4, Y4 are, independently, H, D, F, Cl, Br;
- each m, n, q and k are, independently, integers from 0 to 30;
- each p is independently an integer from 0 to 3;
- L is independently selected from the following structure:
- wherein each X, Y, Z, X1, Y1, Z1, X2, Y2, X3, Y3, X4, Y4 are, independently, H, D, F, Cl, Br;
- each m, n and k are, independently, integers from 0 to 30;
- each p is independently an integer from 0 to 3;
- (b) wherein at least one of A1, A2 is selected, independently, from the following structure:
- and (C) wherein at least one of B1, B2 is selected, independently, from the following structure:
8 more elements
21-23. (canceled)
Dependencies are inferred from the claim text.