Compositions and methods for targeting o-linked n-acetylglucosamine transferase and promoting wound healing
AssigneeThe University of North Carolina at Chapel Hill
InventorsDavid Rubenstein, Kasper Runager
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Abstract
The presently disclosed subject matter provides compounds, compositions, and methods for targeting UDP-N-acetylglucosamine polypeptide β-N-acetylglucosaminyl transferase (OGT). Further, the presently disclosed subject matter provides compounds, compositions, and methods for promoting wound healing.
Claims36
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A pharmaceutical composition comprising
- (i) an antisense OGT polynucleotide, wherein the polynucleotide is 18-30 nucleotides in length and has a sequence that hybridizes to OGT mRNA;
- and
- (ii) a pharmaceutically acceptable carrier.
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A method of treating a subject having a wound, comprising administering an anti-OGT agent to the subject, wherein the anti-OGT agent is chosen from
- (i) an antisense OGT polynucleotide, wherein the polynucleotide is 18-30 nucleotides in length and has a sequence that hybridizes to OGT mRNA;
- (ii) a double stranded RNA molecule that inhibits expression of OGT;
- and
- (iii) a short hairpin RNA molecule that inhibits expression of OGT.
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Dependencies are inferred from the claim text.