Oncolytic rhabdovirus
AssigneeTurnstone Limited Patnership
InventorsDavid F. STOJDL, John BELL
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Abstract
Embodiments of the invention include compositions and methods related to non-VSV rhabdoviruses and their use as anti-cancer therapeutics. Such rhabdoviruses possess tumor cell killing properties in vitro and in vivo.
Claims24
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an oncolytic recombinant rhabdovirus encoding a G protein from a first rhabdovirus and M, P, N and L proteins from a second rhabdovirus.
A method for treating cancer in a subject comprising administering to the subject an effective amount of an oncolytic recombinant rhabdovirus encoding a G protein from a first rhabdovirus and M, P, N and L proteins from a second rhabdovirus.
Dependencies are inferred from the claim text.