Peptides including a binding domain of the viral phosphoprotein (p) subunit to the viral rna free nucleoprotein (n0)
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS), Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon (ENS de Lyon), Universite Grenoble Alpes
InventorsViktor VOLCHKOV, Marc JAMIN, Philip LAWRENCE, Filip YABUKARSKI
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Abstract
The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.
Claims23
An isolated peptide of at most 100 amino-acids comprising an amino acid sequence of formula (I):
- Valine-Xaa1-Xaa2-Glycine-Leucine-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8, wherein
- Xaa1 is glutamine (Q), serine (S), asparagine (N), lysine (K) or an equivalent polar amino acid;
- Xaa2 is glutamic acid (E), aspartic acid (D) asparagine (N), lysine (K), or an equivalent negatively charged (or acid) amino acid;
- Xaa3 is glutamic acid (E), aspartic acid (D), lysine (K) or glutamine (Q), serine (S) or asparagine (N);
- Xaa4 is cysteine (C) or isoleucine (I);
- Xaa5 is isoleucine (I), leucine (L) or valine (V) or an equivalent apolar aliphatic amino acid;
- Xaa6 is glutamine (Q), lysine (K), arginine (R) or aspartic acid (D);
- Xaa7 is alanine (A), or phenylalanine (F) or an equivalent apolar amino acid;
- and
- Xaa8 is isoleucine (I), leucine (L) or valine (V) or an equivalent apolar aliphatic amino acid.
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A method for preventing and/or treating a Paramyxovirinae infection comprising a step of administering at least one isolated peptide derived from a N-terminal phosphoprotein (P) of a Paramyxovirinae virus, having the capacity to inhibit an interaction between the phosphoprotein (P) and the nucleoprotein (N0) of said Paramyxovirinae virus.
Dependencies are inferred from the claim text.