Compositions and methods of enhancing immunogenicity of polysaccharide protein conjugates
AssigneeKanvax Biopharmaceuticals Ltd
InventorJianping LI
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Abstract
The present invention provides compositions and methods for enhancing immunogenicity of polysaccharide antigens. Immunogenic compositions and vaccines comprising polysaccharide-protein conjugates comprising a chimeric carrier protein having a universal epitope are provided. Methods of preparing the compositions, and methods for treating or preventing bacterial infections are further provided. The compositions and methods are useful for enhancing immune response in young children, elderly and immunocompromised individuals.
Claims28
A polysaccharide-protein conjugate comprising a chimeric carrier protein and a polysaccharide antigen, wherein the chimeric carrier protein comprises a carrier protein and a universal epitope, and wherein the polysaccharide antigen is covalently conjugated to the chimeric carrier protein.
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