Multiple-layer immune barrier for donor cells
AssigneeBeta-O2 Technologies Ltd.
InventorsUriel Barkai, Avi Rotem, Yehezkel Bremer, Tova Neufeld
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Abstract
A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.
Claims6
A method for encapsulating a plurality of donor cells, comprising:
- encapsulating the plurality of donor cells in a first alginate structure having a guluronic acid concentration of between 64% and 74%;
- surrounding the first alginate structure by a second alginate structure having a mannuronic acid concentration of between 52% and 60%;
- and
- surrounding the second alginate structure by a selectively-permeable membrane.
The method according to 1, wherein the plurality of donor cells include cells that are disposed in a plurality of pancreatic islets, and wherein encapsulating the plurality of donor cells in the first alginate structure comprises encapsulating the plurality of pancreatic islets in the first alginate structure at a density of between 1500 and 6000 islets per square cm.
Dependencies are inferred from the claim text.