Opsin-binding ligands, compositions and methods of use

A method of treating or preventing an ophthalmic condition in a subject at risk thereof, comprising administering to the subject an effective amount of a compound of Formula I

• wherein R1 and R2 are independently:
• 1) hydrogen,
• 2) —CH3;
• or
• 1) —CH2CH3;
• Ra and Rb are each independently:
• 1) hydrogen,
• 2) CH3, or
• 3) —CH2CH3;
• R3′ and R5 are each independently:
• 1) hydrogen, or
• 2) lower alkyl;
• and
• R4 is:
• 1) hydrogen,
• 2) cycloalkyl, or
• 3) phenyl;
• wherein if either R1 or R2 is hydrogen then each of Ra and Rh is selected from methyl and ethyl, including pharmaceutically acceptable salts, solvates and hydrates thereof.

A method of treating or preventing an ophthalmic condition in a subject at risk thereof, comprising administering to the subject an effective amount of a compound of selected from the group consisting of:

• Name
• Structure
• 7,7-dimethyl-5,6,7,7a-tetrahydro- 1H-inden-2(4H)-one
• (−)-4,4,7,7-tetramethyl-5,6,7,7a- tetrahydro-1H-inden-2(4H)-one
• (+)-4,4,7,7-tetramethyl-5,6,7,7a- tetrahydro-1H-inden-2(4H)-one
• 4,4-dimethyl-5,6,7,7a-tetrahydro- 1H-inden-2(4H)-one
• 4,4,7,7-tetramethyl-5,6,7,7a- tetrahydro-1H-inden-2(4H)-one
• (±)-(3aS,7aS)-3a,7,7- trimethylhexahydro-1H-inden- 2(3H)-one
• (±)-(3aR,7aS)-3,3a,7,7-tetramethyl- 3a,4,5,6,7,7a-hexahydro-1H-inden- 1-one oxime
• 2,7,7-trimethyl-2,3,4,5,6,7- hexahydro-1H-isoindol-1-one
• (±)-(3aR,7aS)-3,3a,7,7-tetramethyl- 3a,4,5,6,7,7a-hexahydro-1H-inden- 1-one
• (±)-(3R,3aR)-3,4,4-trimethyl- 2,3,3a,4,5,6-hexahydro-1H-inden- 1-one
• (3aR,7aS)-4,4,7,7- tetramethylhexahydro-1H-inden- 2(3H)-one
• (±)-(1R,7aS)-1,4,4-trimethyl- 5,6,7,7a-tetrahydro-1H-inden- 2(4H)-one
• (±)-(1R,3aR,7aS)-2,3,3a,7,7- pentamethyl-3a,4,5,6,7,7a- hexahydro 1H inden-1-ol
• (±)-(3aS,7aS)-2,3,4,4-tetramethyl- 3a,4,5,6,7,7a-hexahydro-1H-inden- 1-one
• (±)-(3aS,7aS)-3a,7,7- trimethyloctahydro-1H-inden-2-ol
• (±)-(3aS,7aS)-3a,7,7- trimethylhexahydro-1H-inden- 2(3H)-one oxime
• or a pharmaceutically acceptable salt thereof.