Degassing liquid eluent of a preparative sfc fluid chromatography system

A method of degassing a solution within a system, the method comprising:

• (i) flowing a solution through a degasser, the degasser comprising a continuous body of tubing, having an interior portion and an exterior portion, comprised of a gas permeable material, the degasser having an inlet and an outlet;
• (ii) applying a change in pressure across at least a portion of the degasser to reduce a partial pressure of a component in the solution;
• and
• (iii) conducting the solution from the outlet of the degasser to an inlet of a detector or an inlet of a fraction collector.

A method of degassing a supersaturated solution within a mixed fluid system, comprising:

• (i) providing a gas-liquid separator fluidly connected to a degasser, the degasser comprising a continuous body of tubing, having an interior portion and an exterior portion, comprised of a gas permeable material, the degasser having an inlet connected to the gas-liquid separator and an outlet;
• (ii) separating at least a portion of the supersaturated solution into a gas and a first liquid eluent within the gas-liquid separator;
• (iii) introducing the first liquid eluent from the gas-liquid separator into the inlet of the degasser,
• (iv) applying a differential pressure gradient across the degasser;
• and
• (v) separating an additional portion of the gas from the first liquid eluent, resulting in a second liquid eluent.