Back to results
US 2017/0136045 A1Published application
Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
OwnerEdward T. Weiinventor
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerEdward T. Weiinventor
Estimating the term…
The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-isopropyl-phosphinoyl-alkanes as described herein, DIPA-1-5, DIPA-1-6, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”, that are useful, for example, in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by irritation, itch, or pain); a skin dysesthesia; dermatitis; ocular pain and discomfort; heat discomfort; heat stress; flushing and/or night sweats (vasomotor symptoms); post-operative hypothermia; post-anaesthetic shivering; nasal congestion and nasal obstruction; pharyngeal and esophageal discomfort; fatigue; tiredness; depression; cognitive dysfunction; and to enhance cognitive function. The applicant has found that localized delivery of DIPA compounds to the upper eyelid and/or facial skin has an alerting and enhancement effect on behavior and can be used to give a cosmetic refreshing look, to mental alertness, to reduce fatigue, and to improve work output. The present discovery also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy, in diagnosis of neuropathic pain, and in study of TRPM8 function.
A therapeutic article, comprising a compound of Formula 1 therein
A method of relieving sensory discomfort, comprising:
A method of treating cognitive dysfunction or improving cognitive function, comprising:
A therapeutic method, comprising:
A laboratory reagent for the study of TRPM8 functions comprising 1-diisopropyl-phosphinoyl-pentane, 1-diisopropyl-phosphinoyl-hexane, or 1-diisopropyl-phosphinoyl-heptane [DIPA-1-7].
A diagnostic agent for the differential diagnosis of neuropathic versus somatic pain comprising 1-diisopropyl-phosphinoyl-pentane, 1-diisopropyl-phosphinoyl-hexane, or 1-diisopropyl-phosphinoyl-heptane [DIPA-1-7].
A compound for relieving periorbital and ocular discomfort comprising 1-diisopropyl-phosphinoyl-nonane [DIPA-1-9].
A compound for relieving upper digestive tract discomfort comprising 1-diisopropyl-phosphinoyl-nonane [DIPA-1-9].
A compound for relieving nasal cavity discomfort comprising 1-diisopropyl-phosphinoyl-nonane [DIPA-1-9].
A compound for relieving post-menopausal symptoms discomfort comprising-1-diisopropyl-phosphinoyl-nonane [DIPA-1-9].
Dependencies are inferred from the claim text.