Loading patent…
AssigneesDeutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
InventorsGuy UNGERECHTS, Tobias SPECK, Christine ENGELAND, Sascha BOSSOW
Estimating the term…
The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a multispecific binding polypeptide, said multispecific binding polypeptide comprising a first binding domain binding to a surface molecule of an immune cell with antitumor activity, preferably a lymphocyte, more preferably a T cell or a dendritic cell, and a second binding domain binding to a tumor-associated antigen; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
A recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a multispecific binding polypeptide, said multispecific binding polypeptide comprising:
A combined preparation for simultaneous, separate or sequential use comprising at least one virus of the family Paramyxoviridae and at least one multispecific binding polypeptide.
Dependencies are inferred from the claim text.