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US 2017/0128393 A1Published application
Inhibitors and methods of inhibiting bacterial and viral pathogens
AssigneeSiga Technologies, Inc.
InventorsRobert D. ALLEN III, Sean M. AMBERG, Dongcheng DAI, James R. BURGESON, Dennis E. HRUBY
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Abstract
Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
Claims13
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the following general Formula I or a pharmaceutically acceptable salt thereof:
- wherein R1 is selected from the group consisting of:
- H, chloro, methyl, methoxy, ethoxy, nitro and fluoro;
- R2 is selected from the group consisting of:
- H, chloro, methyl, methoxy, trifluoromethyl, propanoylamino and 2-methylpropanoylamino;
- R3 is selected from the group consisting of:
- H, methyl, amino, methylamino, dimethylamino, phenylamino and 3-pyridylamino;
- R4 is selected from the group consisting of:
- H, chloro, methyl, methoxy, trifluoromethyl and trifluoromethoxy;
- and
- R5 is selected from the group consisting of H and methyl.
7 more elements
13-175. (canceled)
Dependencies are inferred from the claim text.