# US 2017/0120073 A1 · Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors

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- Number: US 2017/0120073 A1
- Document ID: US20170120073A1
- Status: Published application
- Kind: A1
- Application number: 15/349,455
- Filed: 2016-11-11
- Published: 2017-05-04
- Earliest claimed: 2013-03-15
- Assignees: GammaTile LLC
- Applicants: GammaTile LLC
- Inventors: David Brachman; Peter Nakaji; Heyoung McBride; Emad Youssef; Theresa Thomas
- Web page: https://patentgrep.com/patent/US20170120073A1

## CPC

- A61N 5/1007: {Arrangements or means for the introduction of sources into the body}
- A61N 5/1015: {Treatment of resected cavities created by surgery, e.g. lumpectomy}
- A61N 2005/1011: {Apparatus for permanent insertion of sources}
- A61N 2005/1024: {Seeds}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.

## Claims

### Claim 1

A treatment system comprising:
an introducer adapted to engage with a radioactive seed carrier to maintain position of the radioactive seed carrier with reference to the introducer while the radioactive seed carrier is implanted into a cavity of a mammal, wherein the radioactive seed carrier is permanently implantable into the mammal and the introducer is removable from the radioactive seed carrier after implantation of the radioactive seed carrier into the mammal;
the radioactive seed carrier comprising:
an engagement interface configured to engage with the introducer; and
one or more flexible elongate members each having:
a proximal end;
a distal end; and
a carrier portion between the proximal end and the distal end, the carrier portion embedding a radioactive seed;
wherein the radioactive seed carrier is adapted to transform between a first state and a second state in response to movement of the introducer engaged with the engagement interface of the radioactive seed carrier, wherein
the first state is adapted to maintain the one or more elongate members in a substantially linear arrangement; and
the second state is attained by flexing each of the one or more elongate members to engage with one or more surfaces of the cavity.