New derivatives of cephalosporin for treating cancer
AssigneesInstitut Curie, Harmonic Pharma
InventorsARNAUD SINAN KARABOGA, VIOLETA ISABEL PEREZ-NUENO, MICHEL SOUCHET, DIDIER DECAUDIN
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Abstract
The present invention relates to a new class of cephalosporin derivatives of formula (I), notably having CXCR4 receptor antagonist effect, useful as a therapeutic agent for treating cancer, in particular for treating breast cancer, lung cancer and uveal melanoma. The invention further relates to a pharmaceutical composition comprising a compound of formula (I) and an additional antitumor drug for treating cancer.
Claims20
1-17. (canceled)
A method for treating a cancer, comprising administering an effective amount of a compound of formula (I):
- wherein:
- R1 represents:
- a hydrogen atom, or
- a —CO—R4 unit or a —CO2—R4 unit wherein R4 represents a radical (C1-C10)alkyl, (C2-C10)alkylene, (C3-C14)cycloalkyl, heterocycloalkyl, aryl, heteroaryl, (C1-C6)alkyl-(C3-C14)cycloalkyl, (C1-C6)alkyl-heterocycloalkyl, (C1-C6)alkyl-(C3-C14)cycloalkyloxy, (C1-C6)alkyl-heterocycloalkyl oxy, (C1-C6)alkyl-aryl, (C1-C6)alkyl-aryloxy, (C1-C6)alkyl-heteroaryl, or (C1-C6)alkyl-heteroaryloxy, said radicals being optionally substituted by at least one (C1-C6)alkyl group, one hydroxy group, one ketone, one (C1-C6)alkoxy group, one carboxylic acid group eventually substituted by a (C1-C6)alkyl group, one —NR5R6 unit wherein R5 and R6 represent a hydrogen atom or a (C1-C6)alkyl group, one halogen atom, one cyano group, or one nitro group;
- R2 represents a hydrogen atom or a (C1-C6)alkyl chain;
- and
- R3 represents a hydrogen atom, or a (C1-C6)alkyl chain, or (C2-C6)alkylene, said chains being optionally substituted by at least one (C1-C6)alkyl group, one hydroxy group, one —O—CO—(C1-C6)alkyl unit, one ketone, one carboxylic acid group eventually substituted by a (C1-C6)alkyl group, one —NR5R6 unit wherein R5 and R6 represent H or a (C1-C6)alkyl group, one halogen atom, one cyano group or one nitro group;
- or one of its pharmaceutically acceptable salts, in a subject in need thereof.
Dependencies are inferred from the claim text.