Self-assembling nanoparticle drug delivery system
OwnerMiguel A. de los Rios, Kenneth J. Ohinventors
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Abstract
A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the drug, a lipid bi-layer envelope and targeting or facilitating molecules anchored in the lipid bilayer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.
Claims24
A self-assembling nanoparticle drug delivery system comprising:
- a capsid comprised of viral capsid proteins;
- a drug captured in said capsid;
- and
- a lipid bi-layer enveloping said capsid.
A method for constructing a self-assembling nanoparticle drug delivery system comprising:
- mixing a drug with HBV core protein to form a cage solution;
- encapsulating said drug in the core protein cage by raising the ionic strength of said cage solution;
- adding phospholipids to said cage solution;
- adding cholesterol-tagged polyethylene glycol to said cage solution;
- adding cholesterol-tagged protein transduction domain to said cage solution;
- purifying said nanoparticles by centrifugation or size exclusion chromatography.
A method of treating disease with a self-assembling nanoparticle drug delivery system comprising delivering said nanoparticles across a mucosal surface.
Dependencies are inferred from the claim text.