Heteroatom containing substituted fatty acids

A method for treating a condition selected from the group consisting of arterial stenosis, burns, hypertension, obesity, neurodegenerative disorders, skin disorders, arthritis, autoimmune disease, autoinflammatory disease, lupus, Lyme's disease, gout, sepsis, hyperthermia, ulcers, enterocolitis, osteoporosis, viral or bacterial infections, cytomegalovirus, periodontal disease, glomerulonephritis, sarcoidosis, lung disease, chronic lung injury, respiratory distress, lung inflammation, fibrosis of the lung, asthma, acquired respiratory distress syndrome, tobacco induced lung disease, granuloma formation, fibrosis of the liver, graft vs. host disease, postsurgical inflammation, coronary and peripheral vessel restenosis following angioplasty, stent placement or bypass graft, acute and chronic leukemia, B lymphocyte leukemia, neoplastic diseases, arteriosclerosis, atherosclerosis, myocardial inflammation, psoriasis, immunodeficiency, disseminated intravascular coagulation, systemic sclerosis, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, encephalomyelitis, edema, inflammatory bowel disease, hyper IgE syndrome, cancer metastasis or growth, adoptive immune therapy, reperfusion syndrome, radiation burns, and alopecia, the method comprising administering to a subject in need of treatment an effective amount of an unsaturated or polyunsaturated aliphatic chain or a pharmaceutically acceptable salt having one or more heteroatoms positioned anywhere on the aliphatic chain and one or more electron withdrawing group and metabolites or prodrugs thereof, wherein the at least one of the one or more electron withdrawing groups are positioned immediately adjacent to the heteroatom or carbon-carbon double bond or immediately adjacent to a carbon immediately adjacent to the heteroatom or carbon-carbon double bond.