Modified surfaces for attachment of biological materials
AssigneeNortheastern University
InventorsDANIEL M. STOREY, TERRENCE S. MCGRATH, ALEXANDER B. REISING
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Abstract
The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under appropriate conditions. Fibroblasts and endothelial cells exhibit good attachment and growth on most coated substrates, except on nano surfaced structured silicone.
Claims23
An article comprising:
- a substrate having a microstructure surface;
- and
- a nanostructure disposed on the surface, wherein the nanostructure substrate surface enhances osteoblast proliferation compared to the uncoated substrate.
An article comprising:
- a substrate having a microstructure surface;
- and
- a nanostructure disposed on the surface, wherein the nanostructure substrate surface enhances at least one of cell adhesion, proliferation, growth and cell density.
An article comprising:
- a thermoset substrate having a microstructure surface;
- and
- a nanostructure disposed on the surface, wherein the nanostructure substrate surface decreases osteoblast proliferation compared to an uncoated substrate.
Dependencies are inferred from the claim text.