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US 2017/0107483 A1Published application
Method of producing in vitro testicular constructs and uses thereof
AssigneeWake Forest University Health Sciences
InventorsSamuel Pendergraft, Hooman Sadri-Ardekani, Anthony Atala, Colin Bishop
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Abstract
A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.
Claims27
A cell composition useful for making artificial testicular constructs, the composition comprising, in combination:
- (a) spermatogonial stem cells,
- (b) immortalized Sertoli cells, and
- (c) immortalized Leydig cells.
Dependencies are inferred from the claim text.