Photodynamic diagnosis, formulations usable as photosensitizers for this purpose, method for the production and use thereof
AssigneeSanochemia Pharmazeutika AG
InventorsStefan WELZIG, Beate KALZ, Jozsef GUNGL, Klaus GERDES, Werner FRANTSITS, Christina ABRAHAMSBERG
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Abstract
In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.
Claims19
A method for photodynamic diagnosis of tumors, comprising:
- photosensitizing with a photosensitizer that is a stable complex or a stable compound of a sodium or potassium salt of hypericin and a polymeric complexing agent selected from the group consisting of polethylene glycol and poly-N-vinyl amide, the photosensitizer containing 0.225 mg of hypericin.
- wherein the photosensitizer is obtained from a lyophilizate obtained from a solution of the sodium or potassium metal salt of hypericin, the polymeric complexing agent and a buffer system comprising a phosphate buffer or a citric acid buffer.
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A formulation for photodynamic diagnosis of tumors, containing hypericin that is bonded or complexed to a polymeric complexing agent, wherein the hypericin is present as a salt.
A method for preparing a lyophilizate from which a photosensitizer for photodynamic diagnosis of tumors my be obtained, comprising the following successive steps:
- a) preparing a solution of a sodium or potassium salt of hypericin;
- b) dissolving a complexing agent selected from the group consisting of polethylene glycol and poly-N-vinyl amide in the solution;
- c) adding sufficient of a buffer system comprising a phosphate buffer or a citric acid buffer to obtain a concentration of 0.0225 mg hypericin/g solution;
- and
- d) lyophilizing the solution to obtain lyophilizate to yield 0.225 mg hypericin in each resulting obtained photosensitizer.
Dependencies are inferred from the claim text.