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US 2017/0080081 A1Published application
Paramyxovirus Immunogens and Related Materials and Methods
AssigneeOhio State Innovation Foundation
InventorsJianrong Li, Yu Zhang, Rongzhang Wang
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Abstract
Described herein are methyltransferase (MTase)-defective recombinant viruses as vaccines for human metapneumovirus (hMPV), human respiratory syncytial virus (hRSV), and human parainfluenza virus type 3 (PIV3); as well as related materials and methods.
Claims13
A recombinant paramyxovirus composition comprising a nucleic acid molecule which encodes a defective mRNA cap MTase in large (L) polymerase gene in a paramyxovirus viral genome;
- wherein the nucleic acid molecule which encodes a defective mRNA cap MTase carries at least one mutation in the MTase catalytic site;
- wherein the at least one mutation in the MTase catalytic site is in at least one of the K-D-K-E tetrad sites;
- and,
- wherein the paramyxovirus is human metapneumovirus (hMPV) and the at least one K-D-K-E tetrad site mutation is at least one of rhMPV-K1673A, rhMPV-D1779A, rhMPV-K1817A, rhMPV-E1848A, and rhMPV-E1848Q.
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Dependencies are inferred from the claim text.