Compositions and methods for the treatment of diabetes and pre-diabetes
OwnerMohan Murali Alapatiinventor
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Abstract
The invention relates to the compounds and compositions of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprises a salt of dipeptidyl peptidase-4 inhibitor and the methods for treating or preventing metabolic syndrome, prediabetes and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compounds and compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
Claims18
A compound of Formula I:
- or pharmaceutically acceptable salts, hydrates, solvates, crystals, esters, enantiomers, or stereoisomers thereof, or mixtures thereof, wherein:
- RH independently represents
- and
- wherein R1 represents NO2 and R2 represents OH or OD.
A compound of Formula II:
- or pharmaceutically acceptable salts, hydrates, solvates, crystals, esters, enantiomers, or stereoisomers thereof, or mixtures thereof, wherein:
- RH independently represents
- and
- wherein R1 represents NO2 and R2 represents OH or OD.
A compound of Formula V:
- or pharmaceutically acceptable salts, hydrates, solvates, crystals, esters, enantiomers, or stereoisomers thereof, or mixtures thereof, wherein:
- RH independently represents
- and
- wherein R1 represents NO2 and R2 represents OH or OD.
Dependencies are inferred from the claim text.